| All-time record | Played 2265, Won 955, Drawn 431, Lost 879 |
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| Record win in all competitions | Real San Domingo 8–0 Clifton Albion — 1989/90 Islands League |
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| Record home win in all competitions | Real San Domingo 8–0 Clifton Albion — 1989/90 Islands League |
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| Record away win in all competitions | Racing Club 1–7 Real San Domingo — 2015/16 Islands First Division |
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| Record win in the league | Real San Domingo 8–0 Clifton Albion — 1989/90 Islands League |
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| Record home win in the league | Real San Domingo 8–0 Clifton Albion — 1989/90 Islands League |
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| Record away win in the league | Racing Club 1–7 Real San Domingo — 2015/16 Islands First Division |
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| Record loss in all competitions | Port Bristol Rovers 7–0 Real San Domingo — 1985/86 Beta League |
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| Record home loss in all competitions | Real San Domingo 0–6 FC Brados — 2005/06 FA Cup Third Round, Real San Domingo 0–6 Bricknell Town — 2011/12 Islands League |
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| Record away loss in all competitions | Port Bristol Rovers 7–0 Real San Domingo — 1985/86 Beta League |
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| Record loss in the league | Port Bristol Rovers 7–0 Real San Domingo — 1985/86 Beta League |
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| Record home loss in the league | Real San Domingo 0–6 Bricknell Town — 2011/12 Islands League |
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| Record away loss in the league | Port Bristol Rovers 7–0 Real San Domingo — 1985/86 Beta League |
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| Highest scoring game | Real San Domingo 5–5 Adelaide Wanderers — 2021/22 Islands League |
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| Most consecutive league wins | 11 — 2019/20–2020/21 |
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| Most consecutive league draws | 4 — 2000/01, 2005/06, 2013/14 |
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| Most consecutive league defeats | 10 — 2003/04 |
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| Most consecutive league games without defeat | 20 — 1982/83, 2022/23 |
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| Most consecutive league games without victory | 21 — 1986/87–1987/88 |
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| Most consecutive home league wins | 10 — 2001/02, 2010/11–2011/12 |
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| Most consecutive home league defeats | 6 — 1976/77 |
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| Most consecutive away league wins | 7 — 1982/83 |
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| Most consecutive away league defeats | 10 — 2011/12–2012/13, 2014/15 |
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| Most consecutive home league games without defeat | 19 — 2001/02–2003/04 |
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| Most consecutive home league games without victory | 16 — 1976/77–1977/78 |
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| Most consecutive away league games without defeat | 14 — 2021/22–2022/23 |
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| Most consecutive away league games without victory | 22 — 2011/12–2013/14 |
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