| All-time record | Played 1843, Won 691, Drawn 336, Lost 816 |
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| Record win in all competitions | Worthington Rovers 0–7 Durham West End — 2009/10 Islands First Division |
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| Record home win in all competitions | Durham West End 5–0 AFC Droy — 1992/93 Islands First Division, Durham West End 5–0 Kintyre Coastguard — 2000/01 Islands First Division, Durham West End 5–0 Jostinians — 2018/19 FA Cup First Round, Durham West End 5–0 Edwalton — 2018/19 Islands First Division, Durham West End 5–0 Lansdowne 1981 — 2024/25 Islands First Division |
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| Record away win in all competitions | Worthington Rovers 0–7 Durham West End — 2009/10 Islands First Division |
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| Record win in the league | Worthington Rovers 0–7 Durham West End — 2009/10 Islands First Division |
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| Record home win in the league | Durham West End 5–0 AFC Droy — 1992/93 Islands First Division, Durham West End 5–0 Kintyre Coastguard — 2000/01 Islands First Division, Durham West End 5–0 Edwalton — 2018/19 Islands First Division, Durham West End 5–0 Lansdowne 1981 — 2024/25 Islands First Division |
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| Record away win in the league | Worthington Rovers 0–7 Durham West End — 2009/10 Islands First Division |
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| Record loss in all competitions | Kirkby Harriers 7–0 Durham West End — 2005/06 Islands League, Carmichael Town 7–0 Durham West End — 2005/06 Islands League, Durham West End 0–7 Whitburn Carew — 2024/25 FA Cup First Round |
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| Record home loss in all competitions | Durham West End 0–7 Whitburn Carew — 2024/25 FA Cup First Round |
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| Record away loss in all competitions | Kirkby Harriers 7–0 Durham West End — 2005/06 Islands League, Carmichael Town 7–0 Durham West End — 2005/06 Islands League |
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| Record loss in the league | Kirkby Harriers 7–0 Durham West End — 2005/06 Islands League, Carmichael Town 7–0 Durham West End — 2005/06 Islands League |
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| Record home loss in the league | Durham West End 0–6 Deportivo León — 1991/92 Islands League, Durham West End 0–6 Port Bristol Rovers — 2010/11 Islands League, Durham West End 0–6 Adelaide Wanderers — 2017/18 Islands League |
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| Record away loss in the league | Kirkby Harriers 7–0 Durham West End — 2005/06 Islands League, Carmichael Town 7–0 Durham West End — 2005/06 Islands League |
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| Highest scoring game | Torpedo Webbstown 6–3 Durham West End — 1990/91 FA Cup First Round |
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| Most consecutive league wins | 8 — 2000/01, 2009/10 |
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| Most consecutive league draws | 4 — 1981/82, 2013/14 |
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| Most consecutive league defeats | 9 — 1983/84, 2012/13 |
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| Most consecutive league games without defeat | 17 — 2018/19 |
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| Most consecutive league games without victory | 20 — 2012/13 |
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| Most consecutive home league wins | 14 — 1982/83 |
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| Most consecutive home league defeats | 6 — 1991/92 |
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| Most consecutive away league wins | 5 — 2000/01, 2008/09–2009/10, 2017/18–2018/19 |
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| Most consecutive away league defeats | 10 — 1996/97, 2010/11–2011/12 |
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| Most consecutive home league games without defeat | 18 — 1987/88–1988/89 |
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| Most consecutive home league games without victory | 10 — 2012/13 |
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| Most consecutive away league games without defeat | 9 — 2018/19 |
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| Most consecutive away league games without victory | 23 — 1990/91–1991/92 |
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