| All-time record | Played 1877, Won 748, Drawn 332, Lost 797 |
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| Record win in all competitions | Hoxbeth Amateurs 0–7 Santiago de Brados — 1991/92 Islands First Division, Clevedon Magna 0–7 Santiago de Brados — 2013/14 FA Cup Second Round, Santiago de Brados 7–0 Lansdowne 1981 — 2023/24 Islands First Division |
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| Record home win in all competitions | Santiago de Brados 7–0 Lansdowne 1981 — 2023/24 Islands First Division |
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| Record away win in all competitions | Hoxbeth Amateurs 0–7 Santiago de Brados — 1991/92 Islands First Division, Clevedon Magna 0–7 Santiago de Brados — 2013/14 FA Cup Second Round |
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| Record win in the league | Hoxbeth Amateurs 0–7 Santiago de Brados — 1991/92 Islands First Division, Santiago de Brados 7–0 Lansdowne 1981 — 2023/24 Islands First Division |
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| Record home win in the league | Santiago de Brados 7–0 Lansdowne 1981 — 2023/24 Islands First Division |
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| Record away win in the league | Hoxbeth Amateurs 0–7 Santiago de Brados — 1991/92 Islands First Division |
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| Record loss in all competitions | Dockside Admirals 7–0 Santiago de Brados — 1998/99 Islands League, Warfield Industrial 7–0 Santiago de Brados — 2023/24 FA Cup Fourth Round, Walpool Seagulls 7–0 Santiago de Brados — 2023/24 Brados Cup First Round |
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| Record home loss in all competitions | Santiago de Brados 1–6 Clevedon Magna — 1983/84 FA Cup First Round, Santiago de Brados 0–5 St Vincent All Stars — 1998/99 Islands League, Santiago de Brados 0–5 Warfield Industrial — 2001/02 FA Cup Third Round |
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| Record away loss in all competitions | Dockside Admirals 7–0 Santiago de Brados — 1998/99 Islands League, Warfield Industrial 7–0 Santiago de Brados — 2023/24 FA Cup Fourth Round, Walpool Seagulls 7–0 Santiago de Brados — 2023/24 Brados Cup First Round |
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| Record loss in the league | Dockside Admirals 7–0 Santiago de Brados — 1998/99 Islands League |
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| Record home loss in the league | Santiago de Brados 0–5 St Vincent All Stars — 1998/99 Islands League |
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| Record away loss in the league | Dockside Admirals 7–0 Santiago de Brados — 1998/99 Islands League |
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| Highest scoring game | Sunnymede Rangers 7–2 Santiago de Brados — 2021/22 FA Cup First Round, Georgetown Atlantic 6–3 Santiago de Brados — 2022/23 Islands League |
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| Most consecutive league wins | 8 — 1994/95, 2006/07 |
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| Most consecutive league draws | 4 — 2020/21 |
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| Most consecutive league defeats | 11 — 1986/87 |
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| Most consecutive league games without defeat | 15 — 2011/12, 2020/21 |
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| Most consecutive league games without victory | 14 — 2000/01 |
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| Most consecutive home league wins | 8 — 1990/91–1991/92, 1994/95 |
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| Most consecutive home league defeats | 6 — 1992/93 |
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| Most consecutive away league wins | 5 — 1979/80, 2011/12 |
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| Most consecutive away league defeats | 12 — 1985/86–1986/87 |
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| Most consecutive home league games without defeat | 20 — 1984/85–1985/86 |
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| Most consecutive home league games without victory | 13 — 1992/93 |
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| Most consecutive away league games without defeat | 8 — 2024/25 |
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| Most consecutive away league games without victory | 17 — 1985/86–1986/87 |
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